Got some odd ones loaded up today - Charlie
CANADIAN TARIFFS TO GO INTO EFFECT AT MIDNIGHT... BUT AT LEAST WE GOT LAKE AMERICA
Canada's counter-tariffs will go into effect at 12:01 a.m. Eastern Tuesday: about 700 American products, roughly C$27.6 billion worth, taxed at 15, 25 or 50 percent. Steel and aluminum are on the list, and so are processed cheese, motorcycles, washers, dryers, perfume and toilet paper. Finance Minister François-Philippe Champagne called it dollar for dollar, rate for rate, and said that when the US asked too much and offered too little, Canada chose Canada. Industry Minister Mélanie Joly skipped the diplomacy and said the products were picked to squeeze specific American states before the November 3 midterms. This started when Trump's 50% tariffs on about $20 billion of Canadian goods took effect after negotiations collapsed. Who killed the talks depends on who you ask. Carney says the US dropped in last-minute changes that were unfair and uneconomic. Vance and trade rep Jamieson Greer say Ottawa showed up with the 11th-hour demands. Want to know Washington's comeback so far? 50% on Canadian cars, trucks and parts starting January 1, a matching threat on steel that is already sitting at 50%, a Truth Social post announcing he does not want "Canadian anything," and an executive order renaming Lake Ontario to Lake America. In response to the last counterpunch, Carney noted the name is more than 400 years old, vastly predating both Canada and the US. There has been pushback south of the border about the name change as well, with many Americans voicing their displeasure with the name change. MapQuest, a Colorado based GPS company, saw their app shoot to #1 on the US App Store charts in the days following their announcement that they would be sticking with 'Lake Ontario' on their platform.
A DOCUMENTARY JUST PREIMERED THAT IS SO ABSURD EVEN THE DIRECTOR HAD NO IDEA WHAT WAS GOING ON
Sunday night in Telluride, there was a quiet screening for a new documentary: "You Can See Everything," about Elizabeth Holmes co-directed by Nathan Fielder and Lance Oppenheim. The audience was not told about the subject or content of the film until they were in their seats. When they were, phones went into locked pouches, a security team worked the aisles in night-vision goggles, and a programmer took the stage to warn the crowd that anyone who spoiled it was no longer loved. The setup is that Holmes and her partner Billy Evans went to A24 wanting their story documented, and the studio handed the job to the guy from "Nathan for You." Fielder ended up at a San Diego rental house with Holmes, Evans and their two kids during the 34 days before she reported to federal prison in May 2023 to start an 11-year, 3-month sentence for defrauding investors with her health tech firm. He kept going for three years, driven by what he called absolute shock and confusion. The finished film runs 174 minutes. At the post-screening Q&A, Fielder said he is still struggling to understand what he experienced, and that he's hoping audiences can explain it to him. Sections where he communicates with Holmes off camera, including at her prison in Texas, are re-created using an A-list actress whose identity is a plot point he asked the room not to leak. In the teaser, Holmes looks into the lens and says she's not that person, she promises. Nobody in that theater bought it, and that appears to be the whole movie.
DOCTORS WERE USING FOUR GENES FOR OCD AND TOURETTE'S RESEARCH, IT JUST FOUND 32 MORE.
For years the entire high-confidence gene list for OCD and chronic tic disorders sat at four genes. Four. That was the whole biological understanding of conditions that affect up to 2 percent of the population. A Rutgers-led international team ran whole-exome sequencing on nearly 4,000 people diagnosed with OCD, chronic tic disorders like Tourette's, or both, and came back with 32 ones. These are not nudge-the-odds variants. Researchers estimate the identified genes raise the risk of developing these disorders by about 57-fold on average, and as much as 210-fold at the extreme end. Thirty of the 36 turned up in both OCD and tic disorder cases, which is basically what clinicians have watched happen for decades: the two keep landing in the same people and the same families. Some of the genes also overlap with autism, developmental delay and schizophrenia, and they cluster in the brain circuits running impulse control, movement and habit. The team checked their work against congenital heart disease as a control and found no overlap there, so the signal is real. Senior coauthor Jay Tischfield says the genes act in networks rather than individually, and that pharma went from a couple of targets to more than 30. Drastically raising the possibility of new treatments and cures for these diseases.
Sources (3)
- sciencealert.com - Scientists Uncover Shared Genetic Roots of OCD, Tourette Syndrome, And Autism
- ncbi.nlm.nih.gov - The shared genetic risk factors between Tourette syndrome and obsessive-compulsive disorder
- sciencedirect.com - Investigating Shared Genetic Basis Across Tourette Syndrome and Comorbid Neurodevelopmental Disorders
UMPIRE ORDERS ROOKIE TO STRAIGHTEN HIS HAT, ACCIDENTALLY UNIFIES 2 BASEBALL TEAMS
Friday at Coors Field, home plate umpire Doug Eddings stopped play in the sixth to have the catcher relay a message to Cardinals reliever Hancel Rincon: straighten the hat. Rincon, 24, was making his major league debut. He fixed it, retired Hunter Goodman, then gave up a triple, a wild pitch that scored the runner, an inside-the-park homer to Cole Carrigg and a single. Three runs, one out, welcome to the big leagues. Eddings admitted afterward there is no actual rule. He called it "a little unwritten rule," said a Rockies batter had asked whether the tilt was legal, and noted that nobody said anything until Rincon gave up runs. Goodman, the only Rockie who had faced him at that point, said Saturday he never brought it up. Cardinals manager Oli Marmol came out during the pitching change, ate a pitch clock violation mid-argument, got ejected, and was caught on video telling Eddings to "grow the f--k up." His postgame version was tidier saying it was a, power-hungry move, plus gave a list of guys who wore it way more tilted: Dontrelle Willis, CC Sabathia, Pedro Strop. So Saturday, most of the Cardinals warmed up with their hats crooked, kept them crooked in the dugout, and tilted their batting helmets after reaching base. Some Rockies did it too, including Goodman, which is how you know a man has united a clubhouse he does not belong to. Eddings apologized to Rincon on the field before the game. Rincon accepted.
MAINE POLICE CONCLUDE BIGFOOT IS NOT REAL AFTER SITTING DOWN WITH HIM ON MAIN STREET
Last Tuesday in Damariscotta, Maine, the police department got hit with a wave of calls about a tall hairy something strolling around town. About a half dozen calls came in reporting a Bigfoot or Sasquatch-like figure walking around town. He was on Main Street, and he also turned up at the local school during morning drop-off on the first day of classes. First day of school, new backpack, and a Bigfoot in the pickup line. Officer William Smith found the creature sitting peacefully on Main Street, and instead of arresting him for what the department called being "suspiciously hairy," he sat down and had a conversation. The man was a Maine resident who some locals already recognized from a past TV appearance. No crime, no charges, and his motives stayed unclear. Some people called the cops. Others stopped to take pictures, including while the officer was talking to him. Then Chief Erik Josephson wrote the incident up on Facebook and buried every PIO in America. After a "lengthy, exhaustive, and completely serious investigation," the department concluded Bigfoot is not real, and admitted some members had been quietly hoping for something that would finally make national news. It signed off with "Case closed," noting Bigfoot remains at large as long as he puts the costume back on.
Sources (3)
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